VET-CXL®, or veterinary corneal cross-linking, was developed by Vision Engineering Italy to solve the problem of corneal infections in veterinary medicine. The treatment is also indicated for the treatment of inflammatory and degenerative diseases of the cornea. VET-CXL® is performed with VETUVIR® after applying EQUIRVIS® riboflavin eye drops to the cornea.
The scientific evidence on VET-CXL with VETUVIR
The VETUVIR® device is programmed to offer two treatment modes:
- 30 mW/cm2 UV-A power density with 3 minutes irradiation time for the treatment of infectious keratitis and corneal ulcers. The mechanism of action promotes direct bactericidal action (peroxidation of the cell membranes of micro-organisms) and the strengthening of corneal tissue by counteracting bacterial collagenolytic activity (photo-polymerization of stromal proteins);
- 10 mW/cm2 UV-A power density with 9 minutes of irradiation time for the treatment of bullous keratopathy. The mechanism of action favors the strengthening of the corneal tissue by counteracting the excessive edematous imbibition of the cornea.
Arcelli R, Ovidi C, Morera C, Lombardo G, Lombardo M, Marchiegiani A, Gialletti R. Accelerated Cross-Linking for the Treatment of Chronic Corneal Ulcers and Evaluation of Healing with Optical Coherence Tomography (OCT).
Acta Sci Vet Sci 2023; 3-17.
Marchegiani A, Gialletti R, Cassarani MP, Cerquetella M, Attili AR, Lombardo M, Lombardo G, Spaterna A, Arcelli R. Riboflavin/UV-A corneal phototherapy as stand-alone management of ulcerative keratitis in dogs.
Veterinární Medicína 2022; 67: 190-198.
Marchegiani A, Bazzano M, Gialletti R, Cassarani MP, Arcelli R, Orzalesi C, Lombardo G, Lombardo M, Spaterna A. Efficacy of riboflavin/UV-A corneal phototherapy as stand-alone treatment for ulcerative keratitis in horses.
Veterinární Medicína 2021; 66(8).