Clinical Studies

The scientific evidence on Vetuvir and Visioflavin

Infectious keratitis is a corneal disease, which is common in small and large animals, and can result in corneal ulceration with risk of blindness if left untreated.

Current therapy consists of frequent daily administration of antimicrobic and mucolytic eye drops. Efficacy of topical therapy varies according to the initial clinical presentation, the individual response and the frequency of visits.1

Antibiotic resistance is a constantly growing phenomenon.
The use of antibiotics in veterinary medicine is opening serious ethical conflicts2-4

Corneal phototherapy with VETUVIR and VISIOFLAVIN has direct microbicidal action (peroxidation of cell membranes) and reinforces the mechanical strength of the cornea by counteracting collagenolytic activity of microbes (photopolymerization of proteins).

  1. Barbasso E, Peruccio C. Veterinaria 1998; 12: 115-121.
  2. Ministero della Salute, http://www.salute.gov.it/imgs/C_17_opuscoliPoster_234_allegato.pdf
  3. Littmann J, Buyx A, Cars O. Antibiotic resistance: An ethical challenge. Int J Antimicrob Agents 2015; 46(4):359-361.
  4. Shryock TR, Richwine A. The interface between veterinary and human antibiotic use. Ann N Y Acad Sci 2010; 1213: 92-105.

Randomized Controlled Clinical Trial

The clinical study “Assessment of efficacy of corneal phototherapy with riboflavin and UV-A for treating septic corneal ulcers” has been completed at the Universities of Camerino and Perugia. Corneal phototherapy with Vetuvir and Visioflavin has been compared with the standard of care (topical antimicrobials) for treating corneal infections. Vetuvir has been shown to be on average 80% superior to standard of care for treating septic corneal ulcers in dogs and horses! Sign up to our newsletter and we will keep you updated on the clinical outcomes!

Learn more
Assessment of UV-A/riboflavin corneal cross-linking efficacy for the treatment of experimentally induced corneal lesions in an ex vivo animal model
LXXII Convegno SISVET, 2018
Assessment of UV-A/riboflavin corneal cross-linking efficacy for the treatment of experimentally induced corneal lesions in an ex vivo animal model
International CXL experts meeting, 2017